Skin, soft tissue infections succumb to blue light

Tuesday, January 29, 2013

Blue light can selectively eradicate Pseudomonas aeruginosa infections of the skin and soft tissues, while preserving the outermost layer of skin, according to a proof-of-principle study led by Michael R. Hamblin of the Massachusetts General Hospital, and the Harvard Medical School, Boston. The research is published online ahead of print in the journal Antimicrobial Agents and Chemotherapy

"Blue light is a potential non-toxic, non-antibiotic approach for treating skin and soft tissue infections, especially those caused by antibiotic resistant pathogens," says Hamblin.

In the study, animal models were infected with P. aeruginosa. All of the animals in the group treated with blue light survived, while in the control, 82 percent (9 out of 11) of the animals died.

Skin and soft tissue infections are the second most common bacterial infections encountered in clinical practice, and represent the most common infection presentation?more than 3 percent?in patients visiting emergency departments, says Hamblin. The prevalence of skin and soft tissue infections among hospitalized patients is 10 percent, with approximately 14.2 million ambulatory care visits every year and an annual associated medical cost of almost $24 billion (equivalent to $76 for every American), says Hamblin.

Treatment of skin and soft tissue infections has been significantly complicated by the explosion of antibiotic resistance, which may bring an end to what medical scientists refer to as the antibiotic era, says Hamblin. "Microbes replicate very rapidly, and a mutation that helps a microbe survive in the presence of an antibiotic drug will quickly predominate throughout the microbial population. Recently, a dangerous new enzyme, NDM-1, that makes some bacteria resistant to almost all antibiotics available has been found in the United States. Many physicians are concerned that several infections soon may be untreatable."

Besides harming public health, antibiotic resistance boosts health care costs. "Treating resistant skin and soft tissue infections often requires the use of more expensive, or more toxic drugs, and can result in longer hospital stays for infected patients," says Hamblin.

###

T. Dai, A. Gupta, Y.-Y. Huang, R. Yin, C.K. Murray, M.S. Vrahas, M. Sherwood, G.P. Tegos, and M.R. Hamblin, 2013. Blue light rescues mice from potentially fatal Pseudomonas aeruginosa burn infection: efficacy, safety, and mechanism of action. Antim. Agents Chemother. Published ahead of print 21 December 2012 ,doi:10.1128/AAC.01652-12http://www.asm.org/images/Communications/tips/2013/0113blue.pdf

American Society for Microbiology: http://www.asm.org

Thanks to American Society for Microbiology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 46 time(s).

Source: http://www.labspaces.net/126513/Skin__soft_tissue_infections_succumb_to_blue_light

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Cancer drugs give Roche a 2012 profit boost

Growing demand for its cancer medicines and diagnostic tests used by clinical laboratories helped Swiss drug maker Roche Holding AG post a modest 2.4 percent increase in full-year profits.

The Basel-based company said Wednesday that it made a net profit of 9.77 billion Swiss francs ($10.6 billion) in 2012, against 9.54 billion francs the year before, and that it anticipates further gains this year.

The company, which is the world's biggest manufacturer of cancer drugs, said it delivered strong results for 2012 in part due to the launch of its new breast cancer medicine, Perjeta, in the United States and Europe. Overall sales were up 4 percent at 45.5 billion francs ($49.2 billion).

"We met our financial targets, grew faster than the market, and our strong pipeline positions us well for further growth," said Roche CEO Severin Schwan. "A particular highlight in 2012 was the approval of breast cancer medicine Perjeta, which helps women with HER2-positive breast cancer live longer. We now look forward to getting T-DM1, our other novel breast cancer therapy, to patients as soon as possible."

Roche benefits from having strong sellers whose patents are not expiring soon, unlike many of its major competitors. But like most other major Swiss companies it has in recent years battled against the strength of the franc. That somewhat reversed in 2012 with the fall in the franc against the dollar and the yen.

The drug maker said its top-selling products MabThera/Rituxan, Herceptin and Avastin all performed strongly in 2012 as demand grew in all regions. Genentech, which is owned by Roche, makes those three best-selling cancer drugs in the world. Avastin, which had dipped in sales, was "back on the growth path" after its launch for ovarian cancer in Europe at the end of 2011 and was also helped by stronger sales in Japan, the company said.

And the company cited robust demand for its clinical laboratory products in 2012, with the diagnostics division, which launched several new instruments and devices, reporting a 4 percent rise in sales to 10.3 billion francs.

Roche posted an 11 percent rise in 2012 core earnings per share, which rose to 13.62 Swiss francs ($14.74) compared to 12.30 francs a year ago.

Shares in Roche closed Tuesday at 201.40 francs, up 8.5 percent already this year.

Source: http://www.stltoday.com/business/national-and-international/cancer-drugs-give-roche-a-profit-boost/article_ce15925d-1483-53af-9d2e-91ef63876f10.html

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Super Bowl ad brawl has already begun for automakers

9 hrs.

Marty Bernstein , The Detroit Bureau

The hype has begun. Super Bowl XLVII is less than a week away, but the mega-million-buck auto ad brawl is already underway as three of the eight deep-pocket car?advertisers pre-launch their new commercials to NFL fans. The reason? Economics. And a numbers game.

At between $2.4 million?and $4 million per 30-second commercial, ?this amounts to a huge?expenditure for just one airing. But there?s an even bigger number, with more than 115 million Americans predicted to watch?the game Feb. 3.

Until recently, Super Bowl advertising?has been nothing more than putting up the game-day spot and hoping, maybe, that it will trigger some Monday-morning quarterbacking around the water cooler ? with polls and research adding some arguable, additional value. That was then.?

What?s become apparent is that a fairly large percentage of viewers are more interested in the commercials than the game itself. So, how to take advantage of that and extend the payback beyond just a game-day airing that is over in 30 seconds, whether a viewer was sitting in front of the TV or off grabbing something from the refrigerator?

Now, with the various social media,?like Facebook and Twitter as well as YouTube, along with special contests, promotions and PR hype, the shelf life for a good commercial can be dramatically extended to weeks, even months, resulting in additional views extending well into the millions ? even among consumers who ? gasp ? might not have tuned in on Super Bowl Sunday.

Result? The return on investment is as measurable as any ad investment might be. ?And, of course, makers get to battle it out all over for bragging rights as to who was number one.

?(An) early release extends the life of the commercial, builds consumer interest, and most importantly brings early customers into our dealers," said?Steve Shannon, vice president of marketing at Hyundai Motor America.

The?latter reason, arguably, is the most important for buying the commercial in the first place. With that in mind, here are the early commercial entries into this year?s auto ad brawl:?

Mercedes-Benz
During the North American International Auto Show in Detroit, Bernie Glaser, vice president of marketing for Mercedes-Benz, said the company has an enviable role in XLVII.?The game will be played in the Mercedes-Benz Superdome. The ad plan was to pre-release a teaser, but in fact two advance spots were released earlier this week. One sexy little tease spotlighted actress Kate Upton and has already received over 3.4 million hits on YouTube ? but also generated a fury of??negative comments from critics for being overly sexy.?The other is a cinematic mystery tease of what is coming Feb. 3, shot in the Big Easy with some great music.

Hyundai
Like every NFL game, it all begins with the coin toss, and in Super?Bowl?XLVII, Hyundai has the primo commercial position ? a 60-second spot for the new seven-passenger?Santa Fe prior to the heads-or-tails call. Check out the not-so-sneak preview.

There are two in game spots, including another for Santa Fe and one for the turbo Sonata. Hyundai also has bought a couple pre-game ads ? featuring the Genesis R-Spec and Santa Fe. Obviously, the new family-size SUV?is getting the most play. The six commercials pre-game and during the game makes Hyundai the biggest car-vertiser in the big show.?

Audi
More than a tease, the rising luxury car marquee is asking consumers to vote for the favorite end of their sixth Super Bowl commercial. Viewers of the commercial on YouTube were?given?24?hours?to?pick their favorite from three possibilities. The most popular will be added in post-production and will air in advance of the game --?and?in?the enviable commercial position of the first break after kick-off.?

Lincoln Motor Company?and Chevrolet
The newest entry in the auto ad brawl in Super Bowl XLVII is the reborn, revitalized, redesigned, re-engineered Lincoln brand from the renamed Lincoln Motor Company. All previous car companies except Chevrolet have re-upped. Chevy is instead?involved in?the half-time show with Beyonce. As TheDetroitBureau.com previously reported, the pop phenom is expected to receive a new 2014 Chevrolet Corvette Stingray, a special version of the C7 built just for her.?

Copyright 2013 The Detroit Bureau

Source: http://www.nbcnews.com/business/automakers-super-bowl-ad-brawl-has-already-begun-1C8120706

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The Benefits of Internet Marketing in Today's Business Landscape ...

January 29, 2013

| 7 views

Online advertising or internet marketing is the practice of promoting products or services over the internet. Customers will receive advertisements for the product or service typically via the following digital routes: search engine results, social media marketing and banner ads, blog and online classified advertisements, and spam or email advertising. The idea behind internet marketing is to send marketing messages and lure in customers without overdoing it or missing the mark. This article will explore ways in which internet marketing can hit the mark more often.

Pros and Cons of Internet Marketing

Internet Marketing, unlike marketing done on television or through newspapers, has the advantage of being instantly publishable. In addition, the information disseminated through internet marketing activities is virtually unlimited. With a newspaper or television commercial, you are oftentimes targeting one demographic in one particular place. With internet marketing, the advertisements not only hit more people but they are sometimes interactive advertisements that keep customers engaged.

To go Interactive?

More advertising is going interactive these days and it might prove harmful for business not to capitalize on this relatively new way to reach customers. What is interactive advertising? In the most basic sense, interactive advertising is marketing that interacts with the user?s motives or responses to deliver the best service in a timely fashion. For instance, sites like Amazon and Target are interactive in that both sites filter and arrange future searches based on the user?s preferences and purchasing habits. It?s often said that retaining a current customer is ten times less expensive than corralling in a new customer. This economic reality underscores the importance of streamlining interactive advertising to current customers.

One Size Fits Most

Research in internet marketing has shown that two strategies for marketing online pay off in the long run; those strategies are appealing to a specific interest and targeting individuals. The latter, also known as the one-to-one approach, is used in tandem with search engine optimization. With the one-to-one approach, advertisements are based around keywords typed into the search engine. For instance, searching for ?foot locker? might warrant an advertisement for Nike shoes. The one-to-one approach is tremendously time and cost efficient and it often furnishes the customer with just what s/he needs!

Specific Interest Marketing

Another approach, though, is appealing to a specific interest. The specific interest approach focuses on an entire demographic?s shared characteristics, like age or geography. Rather than focusing on one individual, specific interest internet marketing narrows down the advertising to a collective interest or pursuit. For example, internet browsers in Nevada might be presented with Carls Jr. fast food advertisements, which wouldn?t be useful to someone in New England. The specific interest marketing is subtly similar to one-to-one marketing except that specific interest marketing focuses on larger groups of people, perhaps without particular regard to spending habits of those people.

Future of Marketing

Internet marketing is superior to other forms of marketing because it is cost, energy, and resource efficient. There are also more options with internet marketing: internet marketing can solicit millions of people at once or only a few potential customers. With more people flocking to the internet for goods and services, now is the time to incorporate internet marketing into your business.

About Author: Pam Johnson studied sociology and applies her studies of human decision making to internet marketing. She graduated from one of the best sociology programs in the nation and is now VP of Marketing for an internet marketing firm.

If you enjoyed this post, please consider to leave a comment or subscribe to the feed and get future articles delivered to your feed reader.

Source: http://www.naseerahmad.com/2013/01/29/the-benefits-of-internet-marketing-in-todays-business-landscape.html

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Poor sleep in old age prevents the brain from storing memories

Monday, January 28, 2013

The connection between poor sleep, memory loss and brain deterioration as we grow older has been elusive. But for the first time, scientists at the University of California, Berkeley, have found a link between these hallmark maladies of old age. Their discovery opens the door to boosting the quality of sleep in elderly people to improve memory.

UC Berkeley neuroscientists have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus ? which provides short-term storage for memories ? to the prefrontal cortex's longer term "hard drive."

However, in older adults, memories may be getting stuck in the hippocampus due to the poor quality of deep 'slow wave' sleep, and are then overwritten by new memories, the findings suggest.

"What we have discovered is a dysfunctional pathway that helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older ? and with that, a potentially new treatment avenue," said UC Berkeley sleep researcher Matthew Walker, an associate professor of psychology and neuroscience at UC Berkeley and senior author of the study to be published this Sunday, Jan. 27, in the journal Nature Neuroscience.

The findings shed new light on some of the forgetfulness common to the elderly that includes difficulty remembering people's names.

"When we are young, we have deep sleep that helps the brain store and retain new facts and information," Walker said. "But as we get older, the quality of our sleep deteriorates and prevents those memories from being saved by the brain at night."

Healthy adults typically spend one-quarter of the night in deep, non-rapid-eye-movement (REM) sleep. Slow waves are generated by the brain's middle frontal lobe. Deterioration of this frontal region of the brain in elderly people is linked to their failure to generate deep sleep, the study found.

The discovery that slow waves in the frontal brain help strengthen memories paves the way for therapeutic treatments for memory loss in the elderly, such as transcranial direct current stimulation or pharmaceutical remedies. For example, in an earlier study, neuroscientists in Germany successfully used electrical stimulation of the brain in young adults to enhance deep sleep and doubled their overnight memory.

UC Berkeley researchers will be conducting a similar sleep-enhancing study in older adults to see if it will improve their overnight memory. "Can you jumpstart slow wave sleep and help people remember their lives and memories better? It's an exciting possibility," said Bryce Mander, a postdoctoral fellow in psychology at UC Berkeley and lead author of this latest study.

For the UC Berkeley study, Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (mostly in their 70s) after a full night's sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.

As they slept, an electroencephalographic (EEG) machine measured their brain wave activity. The next morning, they were tested again on the word pairs, but this time while undergoing functional and structural Magnetic Resonance Imaging (fMRI) scans.

In older adults, the results showed a clear link between the degree of brain deterioration in the middle frontal lobe and the severity of impaired "slow wave activity" during sleep. On average, the quality of their deep sleep was 75 percent lower than that of the younger participants, and their memory of the word pairs the next day was 55 percent worse.

Meanwhile, in younger adults, brain scans showed that deep sleep had efficiently helped to shift their memories from the short-term storage of the hippocampus to the long-term storage of the prefrontal cortex.

###

University of California - Berkeley: http://www.berkeley.edu

Thanks to University of California - Berkeley for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 60 time(s).

Source: http://www.labspaces.net/126485/Poor_sleep_in_old_age_prevents_the_brain_from_storing_memories

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Dreadball:Copperbowl ? Post Tournament Write-Up!

Sunday 27th January saw Rich Jones run a fantastic one day tournament for Dreadball called Copperbowl. He organised it for the charity ?Help for Heroes? and hoped to get a few like-minded friends turn up and play a few games. What he ended up with was a monster of a tournament with players battling it out on a variety of pitches including the coveted Tabletop Nation pitch!

Rich Jones brings us the details?hot?from his blog:

Evenin? Dreadball fans! Its Quentin Barnes and?Vic the Orx with the impossible to pronounce name here to bring you all the news on today?s Copper Bowl? Proudly Sponsored by ManticCorp Games. ?The best in holo-reality table top gaming?; Tabletop Nation Enterprises ?the only places in the Universes to be seen playing? and Twisties, ?the snack every species loves?. Let me begin by saying if you missed the action today you missed an awesome day of DB action?

They sure did QB, I was so excited all day I almost forgot my second lunch, at one point I almost had to resort to eating that Veer-myn reporter next to me?

Now now Vic, don?t tease the listeners like that? Some may think you are serious, apologise to the gentle folks ?

Sorry QB, sorry folks at home, I wasn?t serious ? He was a skinny little un, wouldn?t have filled me ?

Anyway folks, we could tell at the start of the day that there were going to be quite a few shocks during the day with new coaches and new teams stamping their presence on the more established sides.

That?s right QB there were quite a few new coaches in there, some even with teams in borrowed or ?no sponsored? kit who caused quite a stir. Like my bruvvers from the outer hot zone reaches, the Tohn Gaah, they gave a good account of themselves all day with their new coach, Stevo ?the scarf? Fase.

And the turn up of the tournament, the Plecostomus Knights Corp team, they arrived in borrowed kit, with no sponsor and James B. as their coach, rumour has it they were only formed 24 hours earlier yet breezed through their first two matches with landslide victories, if they hadn?t have run themselves into the pitch by the last match they would have placed higher than their 5^th place I feel.There were 18 teams in all and everyone played 3 matches except for the Kekoa Nai?a and the Corporate Crashers who fell foul to the late arrival of the Crashers meaning they only got to play 3 matches.

Hah hah, there were reports the Kekoa coach Rich ?surfer dude? J was not that laid back and relaxed in the dug out when he heard last minute drop outs to the tournament meant he missed out on any chance of the trophy? You humans are funny, if he?d been an Orx it would have been easy ? Quick visit to the dressing rooms, one quick meal later, one missing coach ? equal teams again, all sorted ?

Vic, Vic, you know those days are over, the DGB agreement on diplomatic immunity for visiting teams doesn?t even stretch that far, you can?t just eat your opposition anymore?

Maybe not QB but things were a damn lot easier when you could ?

To me the major shock of the tournament was how the Green Tray Stackers performed. We had been watching this Forge Fathers team in the pre-season games and their coach. Ian ?Angry Boss? Dawes had them playing awesomely well. On the day they couldn?t seem to do a thing right with a final score of just the one point and a huge strike difference. I?m sure though the Stackers will be a team to watch out for around the tournaments this season.

Or maybe the stuntie little f?

VIC! ? Sorry folks Vics a bit hyped up, he?s been drinking Rad Orx and eating Roast Veermyn flavoured Twisties all day.

Sorry QB, sorry folks at home? What I meant to say was maybe the Forge Fathers are a bit out of their depth playing in the major leagues where they have to play in modified G arenas, not the high G ones of? the FF Minor Leagues?

Try telling that to the teams that got trounced by the Asgard Devils. Their coach Ole ?Smiley? Ellenhoj had them firing all day? their 3^rdrush landslide 7-0 win in the second round of games was on of the highlights of the day. With 3 wins out of the 4 games with the only loss being an over time loss he was doing the Forge Fathers proud.

QB I loved watching the big hits those nippers were putting in on the last game against the Kekoa Nai?a ?Reminded me of my early years, how Alva, the Nai?a striker survived that big hit was beyond me.

The dolphins would have been in trouble if Alva had gone down, Foo was already in line for the re-juve tank after the rush 2 hit, literally, took his head off. Alva looked finished, the gasp the crowd gave when he pulled himself to his feet, even the Asgard Guard shook his hand.?(Alva survived a 9-1 slam )?. The long multi-jump journey from Denmarkius Sector didn?t seem to tire them. Certainly a team to look out for in any tournaments in the Europia Quadrant.

It was probably their kit that put their opponents off QB ? I ain?t seen anything like that since I walked into that bar in So-Ho last time we were in Londonia 1. Asgard Devils more like Asgard?

Vic? what did you make of the eventual winners, the ?Golden Turtles? ? only recently formed but with a long time ManticCorp coach they look like they might be the team to beat this season. Having a clean run, winning the trophy with four landslide victories the human team worked well together.

I don?t know QB, on the face of it it looks like they will stamp over all their opposition this season. But they were not as dominant as they looked. To me it was the shrewd tactic of their coach Leon ?It?s mine? Chapman who took the ?Enforcer? for the last two games while most other coaches were opting for the legal team ?performance enhancing? implants. Granny Orx, was that Enforcer on fire! Although to me QB a jet pack has no place on the DB pitch? No matter who it belongs to. If someone wants to jump so high and long they should have to settle for the old method ? my size 28 boot up their ar?

Vic? I know lots of people would agree with you there but all coaches had access to him and the other DGB MVPs who had been flown in for the tournament.?(from round three the coaches could choose between a MVP, an extra card for 2 coach dice, most went for the dice).?He did make a big impression, especially in that last game where the Hamon Outlaws and their coach Mike Clark could have stolen the trophy if they had pulled off a landslide win. But it was not to be.

The day didn?t pit the father and son coaches against each other thankfully, no one wants to see a family dispute erupt on the benches. Luke ?MR? Wilson and Dominic ?the kid??Wilson?had very differing fortunes on the day? MR and his human side came a very close second place, only the failure to secure a landslide win in the last game kept him out of contention. Meanwhile, I?m afraid the newly formed Orxland Raiders have a lot to learn if they are planning to stay in the Major Leagues?

QB I was ashamed to call them bruvvers ? they even only managed one kill during the day. If I was their clan master there would be some backside whuppin? going on tonight I can tell you.?Wilson?had better get his act together before the sponsors get hungry I can tell you ?. Might be the dearest bit of sashimi ever seen if he don?t get his shi?

Vic? remember we are going out Galactic wide, we don?t want to upset our viewers even more?
Yeh, Sorry QB, sorry folks at home but I was ashamed of them man? At least the Tohn- Gaah bought pride to the Orx family. They took home a trophy, which makes me so proud?
But Vic, wasn?t that a trophy for the best kit, in other words a fashion trophy ? I thought you always said that fashion should stay in the western reaches of the Galactic Quadrants and has nothing to do with the ?one true game? ?

Well QB, I?s got to move with da times ? A trophy is a trophy after all? And in my opinion The Prowlers deserved the most kills trophy?

I?ll remind you of that next time Vic? Talking of Trophies the ?most kills? trophy went, perhaps surprisingly. to the Big Moon Buccaneers, a human team not known for their hard hitting. Their coach must have riled them up before their last game where there two kills made 4 for the tournament and meant they just snatched the trophy.

Let?s turn our attention to the Veer-myn teams, before the tournament the rumour was that this season would be dominated by the Veer-myn teams?

Well QB they sure do taste good with a little garlic, they been dominatin? Orx haute de cwisine for centuries now? Dem roast Veer twisties are growing on me two, last pack I ate only saw me hurlin? like a human on all you can drink and eat galactic cruise?

Vic, you can?t keep going on about how they taste, people find it offensive?

Offensive ? You just have to make sure you cook them well and bang them about a bit to start with to make them more tender like? NO? I mean your comments Vic?
Oh? Sorry QB, sorry folks at home?

The highest placers were the New Orpheus Sneaks, their coach Nick ?beardo? Ellingworth made sure they showed that they were worthy winners of the 15mc third prize chip. Another team to look out for during the season? LV426 Raiders were another Veer-myn team who caused their opposition trouble during the day. White, their coach proved they could, contrary to belief, strike! Teams will not be looking forward to visits from the Raiders this season. The Veerminators, a new team, who were formed just before the tournament impressed with their mid table finish, Jonah, their coach, would have taken a lot from the tournament and I?m sure will be figuring in the top places around the quadrant this season. The team which probably, based on what we had seen pre-season, underachieved the most in the tournament was the ?Beer Money? human franchise. Some of us oldies might still remember the franchise from the UFC/WWF glam tournaments shown in the reruns on ISPN channel 00LD?

Only this time QB it appears they were using their Beer Money just before the tournament, they didn?t seem to start playing until the 3^rd match? no Beer for them for a while I imagine, serves them right I reckon, waxing belongs on the car not on a chest?

Now, now Vic? It?s true though many people expected more out of the team, including their coach Rich ?the hair? Cooke? I still feel that there is a lot more to be seen from the Beer Money this season, especially in the ?Twisties Intergalactic Snack? ? the snack every species loves ? League where they currently head the League.

So all in all a fantastic start to the season proper for Dreadball fans throughout the galaxies? Perhaps the words of Chris Wall,? the C3PO human team coach (the team comprises of penal officers who get together for the love of the game) sums the day up when he said,?That was a jolly bloody good day out chaps. I thoroughly enjoyed playing and not beating some of you.?

Rest assured myself and Vic (if they haven?t fired him by then) will be here to bring you all the latest DB news as the season unfolds? Keep safe and may all your strikes be on target!

Hey QB we finished??I?ve?been dying to tell you, I figured why they are called Golden Turtles ? when you put them on their back and smash through the shell the sweat makes them taste just like sea-food ? here?s one I?m just trying?might make me shi?**********TRANSMISSION CUT BY STATION MANAGER**********

Many thanks to Rich Jones for this ace bit of reporting! If you want to get involved with Dreadball grab a team and head on over to the events pages to see when the next one is running!

Source: http://www.beastsofwar.com/tabletop-nation/dreadballcopperbowl-post-tournament-writeup/

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Jane Austen tourism booms as 'Pride and Prejudice' turns 200

9 hrs.

A. Pawlowski , NBC News

When a classic love story has a big birthday, it?s time to have a ball ? literally.

Monday marks the 200th anniversary of the publication of ?Pride and Prejudice,? the Jane Austen novel that introduced feisty heroine Elizabeth Bennet, seemingly aloof Mr. Darcy and a world of manor homes and grand estates that turned England into a dream destination for readers around the globe.

Balls, dances and other special events are taking place this year to celebrate the bicentennial as Austen continues to lure travelers.

?She?s hugely important,? said Meredith Pearson, a spokeswoman for VisitBritain. The country?s national tourism agency maintains a guide for fans eager to experience the "Pride and Prejudice" lifestyle.

?We found that, to this day, because of the popularity of those stories, it?s something that visitors really, really enjoy doing,? Pearson said.

Even if you haven?t read the book, chances are you?re familiar with the plot of ?Pride and Prejudice? after catching the recent film version starring Keira Knightley, seeing ?Bridget Jones? Diary????a modern reboot of the novel ? or watching the blockbuster 1995 BBC mini-series starring Colin Firth, which led to a huge surge in visitors, Pearson noted.

No wonder, then, tourism is booming along Austen?s trail in England, a path that traditionally takes visitors to the resort city of Bath, the verdant landscapes of Derbyshire and the village of Chawton.

The author lived in Bath from 1801 to 1806 and chose the city as the setting for two of her novels. Today, about 60,000 people a year flock to The Jane Austen Centre, which chronicles her Bath experience, said Jennie Rogers, general manager of the attraction.

Besides taking in the Centre?s permanent exhibition and sampling Georgian biscuits, visitors can also try on fashions from Austen?s era ? empire-waist dresses, bonnets, gloves and parasols for the ladies; waistcoats, coats and top hats for the gentlemen.

?Our visitors become overwhelmed when trying on our replica costumes,? Rogers said. ?(They) love the romance of Jane's novels and the way in which they can relate to her character's dilemmas and issues???even today.?

To celebrate the 200th anniversary of ?Pride and Prejudice,? the Centre is hosting an ?International Readathon? on Monday, when dozens of actors, authors and Austen experts will read the book aloud in its entirety during a 12-hour period.

The city of Bath has put together a suggested itinerary for Austen fans, including taking a walk along the Royal Crescent, where the author often strolled, and enjoying afternoon tea in The Pump Room, which was a popular gathering spot during Austen?s era.

If you?d like to dress up and party Austen-style, there?s the Jane Austen Festival Regency Costumed Summer Ball on June 22, which features Regency dancing???the intricate choreography that requires ladies and gentlemen to form lines and circles, and twirl around and bow to each other.

?We hope to dance Mr. Beveridge's Maggot???a dance made popular by the BBC 1995 version of ?Pride and Prejudice,?? said organizer Jackie Herring.

The novel is also the theme of this year?s Bath Jane Austen Festival, scheduled to take place Sept. 13-21, complete with a Mr. Darcy lookalike contest, a masked ball and workshops on how to perfect the Regency look.

Fans who want to stroll through grand estates and gardens featured in the novels should head to the Derbyshire region of England where many of the Austen movies and mini-series were filmed. The district maintains a list of all the locations used in the productions.

Pearson thinks U.S. visitors love the sites because they?re so uniquely British.

?It?s part of that fairly tale, in a way. Because (the U.S. is) such a young country comparatively, the fact that there are these gorgeous old manor houses and country houses ? it really takes people away and it really catches Americans? imagination,? Pearson said.

One such home is Chatsworth House, said to have inspired Pemberley, Mr. Darcy?s estate in ?Pride and Prejudice.?

To see where Austen created some of her characters, visit her former home in Chawton, now transformed into Jane Austen?s House Museum.

This is where the author spent the last eight years of her life and wrote ?Mansfield Park,? ?Emma,? and ?Persuasion.? To celebrate the 200th anniversary of ?Pride and Prejudice,? the museum is displaying first editions of the book, original illustrations and the table where Austen worked.

British tourism officials?? who are still giddy about the Queen?s Diamond Jubilee and all the other events that drew visitors to the region last year???are hoping Austen?s legacy will continue the momentum in 2013.

?It?s a great year to come over and experience all of the literary connections in the UK,? Pearson said.

Source: http://www.nbcnews.com/travel/itineraries/jane-austen-tourism-booms-pride-prejudice-turns-200-1C8091333

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You Can Master the Art of Innovation | Motivational Journal ...

By A Horton ?

We live in an ever changing world. Any casual observer can see that the pace of the change, we see all around us, is speeding up every day and so the best way to survive and to thrive, in this ever changing environment, is to commit to constantly innovate, evolve and grow.

Your commitment to consistent innovation is what will separate you from the followers and make you a true leader, path finder or trail blazer. You will become an achiever, who will stand out, someone who is a trend setter, rather than a trend follower. It is far better to be setting the standards of performance and achievement, which other people will follow than it is to be the person who is constantly trying to catch up.

Uncover how to Innovate once Again

Most of us are born creative and with an innate ability to innovate. At the age of two over 80 % of two year olds test as highly creative. By the time we reach the age of ten, only two percent of people test as creative and this then remains constant throughout our lives. What happens between the age of two and ten, which kills that creativeness and innovativeness in us? It is time to re-awaken your creative and innovative side and to start down the track of super achievement.

Innovation will help you in many ways:

• Innovation is what will help you to create real meaningful and sustainable progress in your life.
• Consistent progress is what will advance your life and business beyond the average.
• Constant innovation will put you ahead of the competitive herd and the status quo.

Innovation has Become a Requisite for Super Achievement

Gone are the days where innovation was reserved for the select few, such as Einstein, Edison and the Wright Brothers. The ever increasing pace of change has made it imperative that everyone, who wants to succeed and excel, must become an excellent innovator or they risk being side-lined, to become just part of the herd or a very small spoke in the wheel of life.

Believe you can Innovate or you Never Will

Innovation is not an event, it is a process. You must first open your mind and believe that you have what it takes to be an innovator. Have the courage to make the crucial mind-set shift and change your beliefs and philosophy. Innovating must become a way of life for you. Make a commitment right now to stop looking at the world and only seeing what is. Make the shift and make a new commitment to look at the world and to constantly search for what could be or in fact should be.

Keep asking a better quality of question

The quality of your life and business is dictated by the quality of the questions you are asking. Learn the art of always asking explorative questions. Questions that will help you unlock possibility and to allow you to constantly flex you innovation muscle.

When you are a true innovator you constantly see the potential within yourself and others. You look for the opportunity for what could be in every event, situation, process, experience or outcome. You are committed to constantly serve, guide, help and solve.

Learn the Art of Observation and Take Action

To become a great innovator you must start by becoming an excellent observer. Study people, your environment, how people operate and live, what they want and need and what challenges they face. As you observe, constantly look for ways to add value to the world and the people around you. As important as it is to come up with new ideas, being creative is not being a true innovator. A true innovator is a person who takes action and makes things happen. They are real implementers of ideas and new strategies.

Innovation is a Doing Word

Creativity is thinking of new things, which will make a difference in the world. Innovation is implementing these changes and making a real and lasting difference to the world. True innovators go way beyond creativity and they become the people that transform people lives. They are the people that turn creative ideas into real and meaningful progress. Innovation is converting creative ideas into marketable products, which will make everyone?s lives better.

When you make this shift in philosophy, you have the courage to once again unlock your creative side and you commit to become a true innovator. You will begin to see the world very differently and every challenge or opportunity, which crosses your path, will present you with new ideas and marketable concepts. These marketable products or services will have so much value that people will want to part with their hard earned resources to get their hands on them and to create meaningful and lasting mutually beneficial relationships with you and your business..

Hi my name is Andrew Horton; I am an inspirational Speaker, Master Teacher, Radio and TV Host, Global Traveler and Author. My area of focus is in the field of human behavior, expanded awareness and enlightenment. I travel the planet constantly researching, learning and seeking ways to unlock the mysteries of the human mind. I delve into the inner workings of the universe, always looking for ways to understand my role in making things better and contributing to the improvement of the human experience. Please visit my website to sign up for a daily inspirational message, by following this link Daily Inspirational Message. This is your daily call to action, a reminder to do things better each day. Visit my website at http://www.andrewhorton.co.za

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Source: http://josiahmitchell.typepad.com/blog/2013/01/you-can-master-the-art-of-innovation-motivational-journal.html

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Altering eye cells may one day restore vision

Jan. 25, 2013 ? Doctors may one day treat some forms of blindness by altering the genetic program of the light-sensing cells of the eye, according to scientists at Washington University School of Medicine in St. Louis.

Working in mice with retinitis pigmentosa, a disease that causes gradual blindness, the researchers reprogrammed the cells in the eye that enable night vision. The change made the cells more similar to other cells that provide sight during daylight hours and prevented degeneration of the retina, the light-sensing structure in the back of the eye. The scientists now are conducting additional tests to confirm that the mice can still see.

"We think it may be significantly easier to preserve vision by modifying existing cells in the eye than it would be to introduce new stem cells," says senior author Joseph Corbo, MD, PhD, assistant professor of pathology and immunology. "A diseased retina is not a hospitable environment for transplanting stem cells."

The study is available in the early online edition of Proceedings of the National Academy of Sciences.

Mutations in more than 200 genes have been linked to various forms of blindness. Efforts are underway to develop gene therapies for some of these conditions.

Rather than seek treatments tailored to individual mutations, Corbo hopes to develop therapies that can alleviate many forms of visual impairment. To make that possible, he studies the genetic factors that allow cells in the developing eye to take on the specialized roles necessary for vision.

The retina has two types of light-sensing cells or photoreceptors. The rods provide night vision, and the cones sense light in the daytime and detect fine visual details.

In retinitis pigmentosa, the rods die first, leaving patients unable to see at night. Daytime vision often remains intact for some time until the cones also die.

Corbo and others have identified several genes that are active in rods or in cones but not in both types of photoreceptors. He wondered whether turning off a key gene that is activated only in rods could protect the cells from the loss of vision characteristic of retinitis pigmentosa.

'"The question was, when retinitis pigmentosa is caused by a mutation in a protein only active in rods, can we reduce or stop vision loss by making the cells less rod-like?" he explains.

The new study focuses on a protein known as Nrl, which influences development of photoreceptors. Cells that make Nrl become rods, while cells that lack the protein become cones. Turning off the Nrl gene in developing mice leads to a retina packed with cone cells.

To see if this rod-to-cone change was possible in adult mice, Corbo created a mouse model of retinitis pigmentosa with an Nrl gene that could be switched on and off by scientists.

"In adult mice, switching off Nrl partially converts the rod cells into cone cells," he says. "Several months later, when the mutant mice normally had very little vision left, we tested the function of their retina."

The test showed a healthier level of electrical activity in the retinas of mice that lacked Nrl, suggesting that the mice could still see.

Corbo now is looking for other critical development factors that can help scientists more fully transform adult rods into cones. He notes that if complete conversion of rods to cones were possible, this therapy could also be helpful for conditions where cone cells die first, such as macular degeneration.

Montana CL, Kolesnikov AV, Shen SQ, Myers CA, Kefalov VJ, Corbo JC. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proceedings of the National Academy of Sciences, online January 14, 2013.

Funding from the National Eye Institute (EY018826 and EY019312), an Institutional Vision Science Training Grant (EY13360) and a grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences at Washington University supported this research.?

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The above story is reprinted from materials provided by Washington University in St. Louis. The original article was written by Michael C. Purdy.

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Journal Reference:

1. C. L. Montana, A. V. Kolesnikov, S. Q. Shen, C. A. Myers, V. J. Kefalov, J. C. Corbo. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1214387110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/bmQWAsLKO80/130128104443.htm

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Sarah Palin Interview After Fox News Departure Addresses Mitt Romney Election Loss, Tea Party 'Fight'

Despite parting ways with Fox News, Former Alaska governor Sarah Palin (R) said she's not done sharing "the message of the beauty of freedom and the imperative of defending our republic" in an exclusive interview with Breitbart News.

The 2008 Republican vice presidential nominee emphasized the 2014 elections, calling focus on the upcoming races "imperative."

"It?s going to be like 2010, but this time around we need to shake up the GOP machine that tries to orchestrate away too much of the will of constitutional conservatives who don?t give a hoot how they do it in D.C.," Palin said. "D.C. is out of touch, obviously."

Palin also reflected on the most recent presidential election, comparing Mitt Romney and Rep. Paul Ryan's 2012 loss to the own defeat she and Sen. John McCain (R-Ariz.) faced in 2008.

"Conservatism didn?t lose. A moderate Republican candidate lost after he was perceived to alienate working class Reagan Democrat and Independent voters who didn?t turn out for him as much as they did for the McCain/Palin ticket in 2008," Palin said. "Granted, those same voters also didn?t turn out for Obama as strongly either."

When asked about her reaction to the media declaring "both you and the Tea Party dead and buried," Palin said she was "raised to never retreat and to pick battles wisely, and all in due season."

"When it comes to defending our republic, we haven?t begun to fight!" Palin said. "But we delight in those who underestimate us."

HuffPost Media reported earlier:

Real Clear Politics was the first to report that Palin ? who reportedly signed a $1 million-a-year contract with the network in 2010 ? will not be renewing it. The New York Times' Brian Stelter later confirmed the news with Fox News.

A "source close to Palin" told RCP that she had turned down a new offer. Fox News merely told the New York Times in a statement that it wished her the best.

Click here to read the full Palin interview with Breitbart News, and watch a video of some of Palin's best Fox News moments above.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/01/26/sarah-palin-interview_n_2559359.html

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'Blood-biting' predator identified

27 January 2013 Last updated at 21:00 ET

Prehistoric remains discovered more than a century ago have been identified as a new species of marine super-predator.

Researchers said the 165-million-year-old creature was distantly related to modern-day crocodiles.

Parts of its skeleton were found near Peterborough in the early 1900s and are held at Glasgow's Hunterian museum.

The species has been named as Tyrannoneustes lythrodectikos, meaning "blood-biting tyrant swimmer".

Scientists found that the partial skeleton - including a jawbone and teeth - belonged to a group of crocodiles that were similar to dolphins.

The animal's pointed, serrated teeth and large gaping jaw meant it would have been suited to feeding on large-bodied prey.

A team of experts led by the University of Edinburgh said it would help scientists better understand how marine reptiles were evolving about 165 million years ago.

'Missing link'

The researchers believe the species represents a missing link between marine crocodiles that fed on small prey, and others that were similar to modern-day killer whales, which fed on larger prey.

Their findings have been published in the Journal of Systematic Palaeontology.

Dr Mark Young of the University of Edinburgh's School of GeoSciences, said: "It is satisfying to be able to classify a specimen that has been unexamined for more than 100 years, and doubly so to find that this discovery improves our understanding of the evolution of marine reptiles."

Dr Neil Clark, palaeontology curator at the Hunterian, said little research had been done on the specimen since it was first listed in 1919.

He added: "It is comforting to know that new species can still be found in museums as new research is carried out on old collections.

"It is not just the new species that are important, but an increase in our understanding of how life evolved and the variety of life forms that existed 163 million years ago in the warm Jurassic seas around what is now Britain."

Source: http://www.bbc.co.uk/news/uk-scotland-21220499#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Davis-White match US record with 5th dance title

OMAHA, Neb. (AP) ? With a world title and an Olympic silver medal of their own already, Meryl Davis and Charlie White were quite happy to share this latest accomplishment.

Davis and White won their fifth straight ice dance crown at the U.S. Figure Skating Championships on Saturday, matching a record held by four other couples. As the audience stood and cheered, Davis knelt close to the ice for several seconds, her head bowed.

"Being in such an elite group of American ice dancers from the past and seeing that we belong with them, it's special," White said. "All the hard work and our families and their dedication, our support group ? you need a lot of things to come together to make that happen, including staying healthy. There are a lot of little things. I'm proud of us for being able to stick with it, and our continuing love for the sport has helped a lot.

"I'm pleased and I couldn't be more proud."

Judy Schwomeyer and James Sladky (1968-72); Judy Blumberg and Michael Seibert (1981-85); Naomi Lang and Peter Tchernyshev (1999-2003); and Tanith Belbin and Ben Agosto (2004-2008) also won five straight titles.

Elizabeth Punsalan and Jerod Swallow also won five, but not in consecutive years.

The Olympic silver medalists and 2011 world champions had had such a big lead after the short dance they had to do little more but step on the ice to win. But they did so much more than that with their dramatic and powerful routine to "Notre Dame de Paris," setting personal bests for both overall score (197.44 points) and free dance (118.42).

They finished more than 20 points ahead ? yes, you read that right ? of Madison Chock and Evan Bates (175.91). Maia and Alex Shibutani were docked a point for an extended lift and finished third (174.21).

Earlier Saturday, Marissa Castelli and Simon Shnapir overcame a big mistake to win their first pairs title.

"Coming to the U.S. Championships is a good time and there's always a positive energy," Davis said. "It's such an honor to come here. I think being able to perform really well pushes us to put out a better performance, and we are honored to get the results that we did."

For generations, Americans weren't even an afterthought in ice dance. They were so far below the world powerhouses it's a good bet the Russians and British didn't even know their names.

But that has changed in the last 10 years, and Davis and White now set the standard in the sport. Their rivalry with Canada's Tessa Virtue and Scott Moir is the best thing going, with the training partners playing a game of "Can you top this?" Virtue and Moir edged the Americans at the Vancouver Olympics, as well as at the 2010 and 2012 world championships. The Americans won the world title in 2011, as well as the last four Grand Prix finals.

Though they have no peers in the United States, that doesn't mean they coast when they come to nationals.

Far from it.

"That energy only pushes us and makes us feel even more excited," Davis said.

Their performance was spellbinding, so intense no one in the arena dared breathe. Every inch of the ice, every nuance of music was filled with intricate and elegant moves, one more difficult than the next. Their skating skills have always been superb, their edge quality so fine that coaches pop in DVDs of them to show their students.

But it is the way they combine the athletic strengths with the beauty and elegance of a dance that makes them so breathtaking. They are a sporting event and a theater show rolled into one. Their lifts can barely be described they were so intricate and innovative. In one, White twirled Davis like a rifle and whipped her from his front to back all while skating and turning at full speed.

They oozed emotion, using the tips of their eyelashes all the way down to the toes of their feet to express the character of the dance, and the audience was as exhausted as Davis and White when they finished.

Chock and Bates and the Shibutanis have the misfortune of trying to compete with that, and there was no way they could come close. At least, not now.

Chock and Bates' lifts are filled with unique positions, and they were done with great speed and control. But it was the love story they displayed to "Dr. Zhivago" that was so delightful. Close your eyes, and you could almost see the horses and the sleigh in the falling snow.

"It's been such a great season," Chock said. "We have been working very hard, and we hope to keep getting better and better from here."

The Shibutanis' routine to "Memoirs of a Geisha" was seamless, the elements flowing from one to the other so perfectly it was impossible to tell where one ended and the next began. The siblings opened with a pairs spin that was better than anything seen during the actual pairs competition earlier in the afternoon, and it lasted for what seemed like forever ? no easy feat to maintain that speed and momentum.

Their twizzles ? traveling spins ? are, simply, exquisite. They are done in perfect unison, right down to the raising of their arms while they spin. Their big flaw was that he held his sister too long on a lift, a mistake they also made in the short dance.

Source: http://news.yahoo.com/davis-white-match-us-record-5th-dance-title-234053501--spt.html

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NAMM 2013 wrap-up: Analog synths, DJ gear, loads of MIDI, mobile peripherals and more

We've managed to pull through music's deafening January gathering just outside of Los Angeles with our hearing still somewhat intact. The last few days have held a wealth of DJ gear from controllers and consoles to portable units. Both Moog and Korg trotted out new analog synthesizers that look quite formidable while remaining rather affordable. As expected, a truckload of wares to outfit a mobile device arsenal were on display from Bluetooth foot controllers to dual-input audio interfaces. And as always, a few surprises crept in as well -- like a MIDI guitar and fully portable, handheld DJ solution. Head on down past the break to get caught up on the happenings that you might've missed as we look for a nice quiet room to recover for a few hours.

Gallery: NAMM 2013 wrap-up

Hands-on posts

• Numark Orbit wireless MIDI DJ controller hands-on (video)
• Stylophone S2 portable analog synthesizer hands-on (video)
• Moog shows off one-of-a-kind Aluminum Voyager and 10th Anniversary Minimoog Voyager at NAMM (eyes-on)
• Pioneer Platinum Edition CDJ2000nexus, DJM-900nexus and RMX-1000 eyes-on
• IK Multimedia iLoud and iLoud Mini hands-on (video)
• Moog Sub Phatty analog synthesizer hands-on (video)
• Akai launches MPC headphone series, we go hands-on
• Numark iDJ Live II DJ controller hands-on (video)
• Korg announces MS-20 mini, we go hands and ears-on (video)
• MIDI spans 30 years at NAMM with Commodore 64 and Animoog (video)
• Roland Cube Lite mini amplifier allows you to control guitar licks, aux input independently (video)
• Visionary Instruments intros the Robocaster MIDI hybrid guitar, we go ears-on (video)
• Apogee One for iOS and Mac hands-on
• PDJ Portable Disc Jockey is a complete DJ system that fits in your pocket, we go hands-on (video)
• IK Multimedia iRig BlueBoard and iRig HD hands-on (video)
• Numark NS7 II Serato DJ controller hands-on (video)
• Artiphon's 'Instrument 1' is an iPhone powered multi-instrument, we go hands-on

Other NAMM-related news

• Moog details Sub Phatty ahead of NAMM, accepts $1,099 pre-orders for March (video)
• Pioneer intros Platinum Edition CDJ-2000nexus, matching mixer and remixer
• IK Multimedia outs iLoud and iLoud Mini speakers, supplies mobile jam sessions
• Numark refreshes iDJ Live, NS7, Mixtrack Pro DJ controllers, intros new Orbit wireless option
• Orange Amps updates its OPC once more: Intel i7, 16GB RAM and a graphics boost
• Apogee revamps One and Duet audio interfaces for iOS and Mac, updates Quartet to match

Filed under: Announcements, Misc, Peripherals

Comments

Source: http://www.engadget.com/2013/01/27/namm-2013-wrap-up/

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EJ Manuel leads South to Senior Bowl win, 21-16

MOBILE, Ala. (AP) ? EJ Manuel's January couldn't have gone much better on the field. More importantly, he's hoping for a similarly happy February for his family.

The Florida State quarterback passed for a touchdown and rushed for another on the South's first two drives in a 21-16 victory over the North in the Senior Bowl on Saturday, and was named Most Outstanding Player.

Now, he can try to be the MOS ? Most Outstanding Son. His mother, Jackie Manuel, who was diagnosed with breast cancer before the season, has been recovering from her final round of chemotherapy, and Manuel said she's scheduled to have surgery on Feb. 1.

"That's kind of been my motivation," Manuel said. "I call my mom every single day and tell her I love her. I never miss a day.

"They'll be sending that award home to her. I won that award for her. I went out there and played well for her. I'm happy I was able to do it."

And even happier to return to her side in Virginia for a few days, instead of just squeezing in Skype and Facetime sessions.

It was a great finish for Manuel to a month that began with a 291-yard performance in an Orange Bowl victory over Northern Illinois.

Manuel and running backs Stepfan Taylor and Mike James combined to put the game for senior NFL prospects away on the South's final drive. Stanford's Taylor carried five times for 32 yards and caught a 6-yard pass from Manuel.

Manuel converted a fourth-and-1 play on a sneak to set up a 5-yard touchdown run for Miami's James with 2:41 left. He completed 7 of 10 passes for 76 yards with a 20-yard touchdown pass to Alabama tight end Michael Williams. He also scored on a 2-yard run.

Brigham Young defensive end Ezekiel Ansah received MOP honors for the South team while Purdue defensive lineman Kawann Short was the North's top player.

Miami, Ohio quarterback Zac Dysert answered with a scoring drive that ended with his 3-yard touchdown pass to Oregon running back Kenjon Barner with 23 seconds left. The two-point conversion and onside kick both failed.

Ansah is a native of Ghana who initially was on the track team and now is a potential first-round pick. He had seven tackles, 3.5 behind the line, 1.5 sacks and a forced fumble.

"It was fun. I came out here to work hard, with a bunch of all-star players, obviously," Ansah said. "Everyone out here is an MVP. I just came here to learn and get better."

Short had three tackles, one for a loss.

Taylor finished with nine carries for 53 yards for the South.

Barner led all receivers with seven catches for 59 yards and gained 13 yards on three carries.

It was an up and down day for most of the quarterbacks.

Arkansas' Tyler Wilson completed 8 of 11 passes for 40 yards for the South. Landry Jones, a four-year starter for Oklahoma, was 3-of-9 passing for 16 yards and was sacked twice.

For the North, Dysert was 10 of 16 for 93 yards and was intercepted once and sacked twice. North Carolina State's Mike Glennon completed half his 16 attempts for 82 yards, and Syracuse's Ryan Nassib was 4 of 10 for 44 yards and threw an interception.

Southeastern Louisiana defensive back Robert Alford set up Manuel's 2-yard run with an 88-yard return of the opening kick. Then Manuel lofted an over-the-shoulder pass to Williams in the end zone.

"The corner played the flat and big Mike ran a great route and got leverage on the linebacker," Manuel said. "I thought it was a great matchup and I just threw the ball up there and he made a great catch."

Williams converted another third-down play with a 19-yard catch on the drive.

Glennon and the North offense finally got things going to open the second half.

He completed all three of his pass attempts for 34 yards and then UCLA's Johnathan Franklin, a finalist for the Doak Walker Award, closed the drive with a 12-yard run and a 20-yard touchdown on consecutive plays.

Manuel didn't play again until the third quarter when he led the South across midfield. His fourth-down pass was deflected into the arms of Utah State defensive back Will Davis for an interception.

Davis returned it 25 yards and Glennon led the North deep enough to set up a 42-yard field goal by Oklahoma State's Quinn Sharp to make it 14-10 with 3:28 left in the third quarter.

Former Michigan quarterback Denard Robinson continued his conversion to receiver. He lost 3 yards on a reverse but turned a screen pass from Nassib into a 14-yard gain late in the third quarter and added a 7-yard catch in the fourth.

Source: http://news.yahoo.com/e-j-manuel-leads-south-senior-bowl-win-005359095--spt.html

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PFT: Rams reportedly will hire Rob Ryan

AP

Few teams are willing to fiddle with their lineup entering the playoffs.

That makes the Ravens? willingness to blow up their offensive line amazing, and the results have justified the decision.

They took former Pro Bowler Bryant McKinnie out of exile on the bench and started him at left tackle, which moved Michael Oher from left to right tackle, and Kelechi Osemele from right tackle to left guard.

But it took McKinnie convicing his coaches after an up-and-down offseason which included weight problems and a late arrival at training camp after he supposedly slipped and injured his back at his home.

The Ravens had allowed 15 sacks in their previous five games, when McKinnie went to coach John Harbaugh prior to the regular season finale.

?I just told him how badly I wanted to play,? McKinnie said, via Matt Zenitz of the Carroll County Times. ?I just felt like I could help and make a difference, and he was like, ?Just show me at practice.??

He apparently did, as their offensive line has stabilized in recent weeks, allowing four sacks in three playoff games, and paving the way for their running backs to be an actual factor in the result (which wasn?t always the case in the regular season).

?It?s just clicked,? Osemele said of the new-look line. ?I don?t know what it is, but, . . . it?s just a good fit.

?We really didn?t even have to take many reps before we realized how dominant we could be.?

McKinnie?s been the key, as he kept pass-rushers Dwight Freeney and Elvis Dumervil at bay, something quarterback Joe Flacco?s thankful for.

? I think it?s a pretty solid group we have up there right now,? Flacco said. ?Bryant?s fresh, playing quick and moving well. And obviously, with his stature out there, he?s a big, strong guy.

?It gives us five really good talents up there and they?re playing well together.?

That it happened when perhaps their most talented player had to beg his way out of the doghouse makes it that much more impressive.

Source: http://profootballtalk.nbcsports.com/2013/01/24/report-rams-will-hire-rob-ryan/related/

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Super Bowl commercials 2013: The 4 best sneak previews

Super Bowl commercials are one of the most anticipated parts of this annual event for many viewers, and now companies are allowing consumers to get sneak peeks at the ads rolling out on game night. As one of the most-watched TV shows (and therefore the most expensive commercial air time), the Super Bowl has become the venue for premiering new TV ads. Here are some of the best Super Bowl commercial previews that companies have released so far this year.

- Molly Driscoll,?Staff Writer

1. Coca-Cola

For many, Super Bowl commercials are the favorite part of this national 'campfire' event. Companies spend millions to snag even a few seconds of airtime during what is often one of the most watched evenings of television in the year.

Last year, in a commercial spot for Acura, comedian Jerry Seinfeld tries to buy the first model of a car available and tries to bribe the person who?s No. 1 in line (it included an appearance by the famous Soup Nazi who featured in one ?Seinfeld? episode), only to be foiled by TV host Jay Leno. Another popular spot was the Honda commercial starring Matthew Broderick, who reprised his role as the title character in ?Ferris Bueller?s Day Off? as he took a vacation from his set and zoomed around town, visiting a carnival and acting out scenes from ?Bueller.?

Many Super Bowl viewers still remember a 2011 commercial from Volkswagen in which a small boy dressed as Darth Vader tries to use the Force to move various objects, including the family dog and a baby doll. He?s simultaneously ecstatic and terrified when the family?s new car starts, thanks to his dad surreptitiously clicking the handheld remote starter.

This year, one of the best commercial previews for 2013 is for Coca-Cola. According to the new spot, three teams ? one of cowboys, one of showgirls, and one of Badlanders (picture Mad Max) ? are racing through a desert to try to reach a giant bottle of Coke first. But there's also a crowdsourcing element to the ad. Viewers can go online to vote for their favorite team and/or sabotage their least favorite. Coke will air the winning ending on Feb. 3. Who will snag the soda first?

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Source: http://rss.csmonitor.com/~r/feeds/csm/~3/pft4yJb6J28/Super-Bowl-commercials-2013-The-4-best-sneak-previews

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Let Internet Marketing Help Your Business Succeed With These Tips ...

It may be hard to start out, particularly if your business has a lot of competition. Internet marketing needs to be tackled with a multi-line strategy. This article can help you figure out how to put the business first.

A good internet marketing strategy should always include giving your customers a money back guarantee if something is not right. This way, you will appear to be a legitimate business and your potential customers will feel like they are safe to trust you with their money. By assuming all of the risk and offering your customers a guarantee, they will be more inclined to trust you.

When creating advertisements for your products and services, include descriptive text that emphasizes how quickly buyers will be satisfied. Quick ship time, results, or ease of ordering are all good ways to see more success with the products and services you offer. What the customer can expect is quick downloads, a fast checkout process and speedy confirmation of orders placed online.

An important tip regarding Internet marketing is to be an expert in anything that you deal with on your site. This is very important because it gives you a great deal of credibility and makes a strong impression on your potential customers.

Don?t be typical when it comes to banner ads. Make your banner stand out from the crowd, and potential buyers will be more likely to click it.

Security is extremely important for every business website. There are a lot of trusted security services. VeriSign is a popular choice but there are many other companies that offer secure transaction services. Although security systems are expensive, they are necessary to protect both the customer and the company.

When planning your Internet marketing strategies, use a variety of techniques and approaches and don?t put all your effort into one narrow pathway. This is especially important when developing a new business. It?s an excellent idea to keep plugging away at your day job until the success of your online venture is assured.

One method for getting new customers is setting up a landing page that allows users to opt-in. This page will ask your visitors for their email address. You can even give them an incentive to sign up like a coupon or promotional item to get them to fill out contact information. That way, they get something nice at no charge and you get to add them to your list.

One option is to ?bundle? merchandise?combine similar items for a single, discounted selling price. Always be honest about the fine print of your marketing.

Make sure you keep good records. It could be traffic, refunds, sales, referrals, or anything else that can be measured on your website. Detailed reports can help you figure out what to do with Internet marketing.

Offer your customers a way to make charitable donations by buying your products. This should be advertised clearly (but not excessively) to your website visitors. The percentage of your profits doesn?t need to be huge to help your marketing.

Use what you have learned to help you focus and devise an effective strategy. As we said before, if you invest some of your time into it you will make or break your online business. Remember, though, that the knowledge you learn is only as good as the implementation of the tactic.

Be sure to visit our friends at SIVA Marketing.

Source: http://internetmarketingforcash.com/?p=2044

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